ProductDescription
1,2-Distearoyl-sn-Glycero-3-Phosphoethanolamine(DSPE)conjugatedpolyethyleneglycolwithdibenzocycolctyne聽(DSPE-PEG-DBCO)isalinearheterobifunctionalPEGylationreagentwithaDSPEphospholipidandanDBCOforCu-freechemistry.DSPEderivativescangoClickchemistryreactionwithoutaneedofanymetalcatalysts.Thestrain-promoted1,3-dipolarcycloadditionofcyclooctynesandazides,alsotermedastheCu-freeclickreaction,isabioorthogonalreactionthatenablestheconjugationoftwomoleculesinaqueoussolution.DBCOreagentscanbeusedtolabelazide-modifiedbiomoleculesspontaneouswithouttheneedfortoxicCucatalysts.Thereactionofazideswithstrainedalkynes,suchascyclooctynes,reADIlyformsatriazoleproductwithouttheneedforatoxiccatalystPEGylationcanincreasesolubilityandstABIlityandreduceimmunogenicityofpeptidesandproteins.Itcanalsosuppressthenon-specificbindingofchargedmoleculestothemodifiedsurfaces.