ProductDescription
Poly(Lactide-co-glycolide)-聽poly(ethyleneglycol)withdibenzocycolctyne聽(PLGA-PEG-DBCO)isalinearheterobifunctionalPEGylationreagentwithaPLGA聽andanDBCOforCu-freechemistry.PLGA-PEG-DBCO聽cangoClickchemistryreactionwithoutaneedofanymetalcatalysts.Thestrain-promoted1,3-dipolarcycloadditionofcyclooctynesandazides,alsotermedastheCu-freeclickreaction,isabioorthogonalreactionthatenablestheconjugationoftwomoleculesinaqueoussolution.DBCOreagentscanbeusedtolabelazide-modifiedbiomoleculesspontaneouswithouttheneedfortoxicCucatalysts.Thereactionofazideswithstrainedalkynes,suchascyclooctynes,reADIlyformsatriazoleproductwithouttheneedforatoxiccatalystPEGylationcanincreasesolubilityandstABIlityandreduceimmunogenicityofpeptidesandproteins.Itcanalsosuppressthenon-specificbindingofchargedmoleculestothemodifiedsurfaces.
Poly(lactide-co-glycolide)-b-poly(ethyleneglycol))isonethemostcommonlyusedbiodegradableamphiphilicblockcopolymers(ABCs)fordrugdeliveryapplications.PEGisthehydrophilicpartandPLGAisthehydrophobicpart.聽Amphiphilicblockcopolymers(AmBC)consisttwochemicallydifferenthomopolymerblocks.Oneoftheblockishydrophilicandtheotheroneishydrophobic.Thesemacromoleculeshavethepropertiestoself-assembleintomicelleswhendissolvedinanaqueousmedia.