ProductDescription
Betalapachone(尾-Lapachone)聽isanaphthoquinonecompoundderivedfrombarkofTabebuiasp.,withantitumor,antibacterial,antifungalandantitrypanosomalactivities.Beta-lapachoneexertsitsanti-tumoreffectbyindirectactionsofinducingp53-independentapoptosisandcellcyclearrestmediatedthroughalteredactivitiesofcellcyclecontrolregulatoryproteins;includingdown-regulatingretinoblastomaprotein(pRB),atranscriptionalrepressortargetattranscriptionfactorE2F-1,aswellasinducesexpressionofcyclindependentkinaseinhibitor1A(CDKN1Aorp21).BothE2F-1andp21arerequiredforG1/S-phasetransitionduringcellcycle.ThisagentalsoinhibitsDNAtopoisomeraseIbyamechanismdistinctfromthatofcamptothecin,andtherebyblockstheformationofacleavablecomplexleADIngtoenzymeinhibitionandpreventDNArepair.FurThermore,beta-lapachonecouldinducereactiveoxygenspeciesinvivo,andresultincytotoxicity.