ProductDescription
TopotecanhydrochlorideisaTopoisomeraseIinhibitor.Itisasemisyntheticderivativeofcamptothecinwithantineoplasticactivity.DuringtheSphaseofthecellcycle,topotecanselectivelystABIlizestopoisomeraseI-DNAcovalentcomplexes,inhibitingreligationoftopoisomeraseI-mediatedsingle-strandDNAbreaksandproducingpotentiallylethaldouble-strandDNAbreakswhencomplexesareencounteredbytheDNAreplicationmachinery.Camptothecinisacytotoxicquinoline-basedalkaloidextractedfromtheAsiantreeCamptothecaacuminata.
TheIC50valuesofTopotecanat24hare2.73卤0.25渭MofU251cells,2.95卤0.23渭MofU87cells,5.46卤0.41渭MofGSCs-U251and5.95卤0.24渭MofGSCs-U87.
TopotecanhydrochloridehydrateissolubleinDMSOataconcentrationthatisgreaterthanorequalto20mg/ml.