ProductDescription
CucurbitacinEisapotentinhibitorofactindepolymerization.CucurbitacinEismoreactivethanjasplakinolide,andhasadifferentmechanismofaction,bindingtoadifferentsite.CucurbitacinEbindsspecificallytofilamentousactin(F-actin)formingacovalentbondatresidueCys257,butnottomonomericactin(G-actin),stABIlizingF-actin,withoutaffectingactinpolymerizationornucleation.