ProductDescription
Copolymersofcationicpoly(ethyleneimine)andpolyethyleneglycol(PEG)(PEI-PEG)areextremelywell-studiedcompoundsthatmarkedlyimprovetheinvitroandinvivodeliveryofoligonucleotides(AOs)tocellsandtissues.ByvaryingtheMwofPEI,aswellasthenatureofPEGshielding,PEG-PEI-AOnanoparticulatescanbepreparedwithadynamicrangeofsize,surfacecharge,andstABIlity.Eachofthesepropertiesin-turninfluencesthetransfectioncapacityofthePEG-PEI-AOpolyplexes.Inaddition,PEG-PEIcopolymersarereADIlyfunctionalizedforenhancedefficacyandspecificityofcellularandtissuetargeting.